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Educate. Thrive.

Your resource for health and wellness information

The B6 Paradox

5/20/2021

29 Comments

 
Vitamin B6 has been widely used in the treatment of morning sickness, and other types of nausea. B6 has been known to have antiemetic effects since the 1940s. There are multiple forms of B6 in blood circulation and knowing which form had the most significant effect on nausea and vomiting had been a bit of a mystery until newer research pointed to the pyridoxal-5-phosphate (P5P) form of B6 as being associated with the decrease in nausea and vomiting symptoms. But, it's not just this simple (of course)

​​B6 for Nausea Support

A study done in 2014 and published in the Journal of Clinical Pharmacology found a correlation between levels of P5P and a decrease in nausea and vomiting symptoms. The results came after an analysis of 283 pregnant women experiencing pregnancy nausea symptoms. The participants were randomized to receive a vitamin B6 medication in the form of pyridoxine hydrochloride or a placebo for 14 days. The effectiveness of the treatment was assessed by the Pregnancy-Unique Quantification of Emesis (PUQE) scoring system. Blood samples were taken on days 0, 4, 8, and 14 to measure the values of the different vitamin B6 forms; pyridoxal, pyridoxine, and P5P.

Among the women in the group receiving the supplemental pyridoxine hydrochloride, PUQE scores consistently improved over the 14 days. When they broke down the blood samples, the values of pyridoxal and pyridoxine remained constant and low, while the blood values of P5P increased in association with the antiemetic effects. 

How cool is that? 

From this study we can deduce that pyridoxine and pyridoxal were preforms of the P5P and that the P5P form was the form with the therapeutic effects. Based on these findings, treatment with the P5P form directly may be more beneficial in treatment than using the pyridoxine HCL form typically found in supplementation. Especially for those women who may have genetic conditions that limit their ability to convert pyridoxine to P5P, or who are insufficient in nutrients needed for conversion to happen. 

The B6 Paradox

There is a little something I want to touch on here, since we’re talking about B6 conversion, called the B6 paradox. We see this in supplements, typically high dose B complexes or isolated B6 supplements. One of the known side effects of B6 overdose is neurotoxicity with tingling in the extremities and neuropathy type presentations. Until 2017, the exact mechanism behind this was unknown. 

In this study they compared the neurological effects of different vitamin B6 forms, pyridoxine, pyridoxamine, pyridoxal, and P5P on several types of cells. What they found was that high doses of pyridoxine cause cell death, while none of the other vitamers affected the viability of the cells. Moreover, the P5P dependent enzymes were inhibited by the high dosed pyridoxine. This explains why symptoms of vitamin B6 toxicity mimic vitamin B6 deficiency since the supplemental pyridoxine causes a deficiency in P5P function. 

This is just one example of why vitamin form in supplementation is important. 

Picture

Author

Sarah Thompson CFMP, L.Ac., Doula is the owner and lead practitioner at Sacred Vessel Acupuncture & Functional Medicine. Sarah as over 20 years of experience in health & wellness, nutrition, private practice alternative medicine, education and speaking

29 Comments
Vital Life Wellness link
11/23/2021 01:52:21 am

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Stephanie
7/23/2024 02:29:26 am

Hello everyone, I am from Wembley, Britain. I want to write this testimony to tell others and thank Dr. Odunga for what he has done for me. The first 12 years of my marriage I had 5 miscarriages and I was called all sorts of names by my mother-in-law and this made my marriage life very hectic and a burden of sorrow. I contacted Dr. Odunga for help and I will say that he is a very strong and honest man and he indeed helped me solve my problem. I saw his email in a testimony and I contacted him, little did I know it would be the end of all my problems. After 2 days of contact, I received a fertility herb and he told me to use it. The herb worked and my husband even loved me more and bought me expensive things. One afternoon, I went to a nearby hospital and came back home with the positive result of my pregnancy and after 9 months I gave birth to a baby boy. Ever since I contacted Dr. Odunga, my story has been different. I have 3 children at present and I am very happy in my marriage. Please, contact him at [email protected] OR Whats App him +2348167159012 to help you too

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Britney
7/23/2024 07:31:45 pm

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Reply
Samuel link
11/28/2023 06:29:42 am

As a tech executive, I've been relying on B-complex supplements to navigate my demanding schedule. The correlation between P5P and reduced nausea is fascinating, and I wonder if incorporating P5P into my supplement routine could have additional benefits for focus. Have you come across any anecdotes or studies supporting the use of P5P-rich B-complex for cognitive enhancement in high-stress professions?

Reply
mark hold
7/4/2024 05:02:37 pm

One faithful day as i was watching a video on you tube i saw a comment of one MR PAUL HAVERSACK testifying of this great herbal healer doctor Moses Buba, That helped him enlarge his manhood .i was shocked and happy, so i quickly visited his website and emailed him within 30 mins he got back to me and told me all i need to buy and i did so after 4 days i received his herbal medicine ,he gave me instructions on how to use it ,as i am speaking to you people now after using the cream for just two weeks my manhood size is 10 inches long and 8.0 girth ,,am so happy and grateful for his work in my life thank you so much Doctor Moses buba ,,i also learnt he has cure for LOW SPERM COUNT,PREMATURE EJACULATION,ERECTILE DYSFUNCTION,HIV/AIDS VIRUS,DIABETES 1/2,HERPES DISEASE, CANCER, and lots more
website:https://bubaherbalmiraclem.wixsite.com/website
Facebook page ;https://www.facebook.com/profile.php?id=61559577240930

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Cheryl Floyd
7/11/2024 07:37:52 pm

My name is Cheryl Floyd. I am the happiest woman on the face of this earth. I am happy because of this man, a great spell who made my dreams come true. This is the handwork of Doctor Odunga. I contacted this man to help me save my marriage. My husband and I have been living without a child for 17 years and this has made me sort help in spells. I contacted Doctor Odunga and only him out of three spell casters did his work for me within 48 hours as he promised and I became pregnant with twins. I have been wanting to write this testimony for so long now when I became pregnant but I waited for the babies to be delivered and I am now a mother of twins, a boy and a girl. What else are you waiting for? Do you want a spell for pregnancy and solve fertility problems? Contact Doctor ODUNGA now at Email: [email protected] OR Whats App/Call +2348167159012 and he will talk to you directly.

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Britney
7/23/2024 07:31:22 pm

NATURAL HERBS IS THE REAL DEAL IN CURING HERPES-1&2, HIV/AIDS, HPV AND CANCER...Contact Dr Osato to get the natural herbs to cure yourself from that horrible disease/virus. I got the herbs from Dr Osato and I made use of it with the instructions he gave to me on how to use the natural herbal product, after usage I went for a checkup and my result was Negative and all the symptoms of herpes were completely gone from my body. I was cured from herpes-1&2 after using Dr Osato natural herbal medicine. You can contact Dr Osato on his email: [email protected] or WhatsApp +2347051705853 to get the herbal medicine from him and his website is https://osatoherbalcure.wordpress.com

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william wirtz
8/1/2024 03:48:42 pm

I recommend you to get your herbal medicine through Herbal Miracle Medicine . He cured me from my herpes outbreak and now I am free . All thanks for your care and giving me my life back . If you are suffering from any illness you can get your medication from Doc Moses Buba on his .
email him on ( [email protected] )
Facebook page: https://www.facebook.com/profile.php?id=61559577240930
website:https://bubaherbalmiraclem.wixsite.com/website

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juana g brown
8/26/2024 03:38:34 pm

Must read! My names are Juana G Brown from US taxes, for a year now i have been living with this virus called HEPES VIRUS and i have been taking some medications from my and there was no improvement, All thanks to God almighty for using Dr Agbomian Sunday for curing my HERPES Virus with the help of his powerful root and herbs...Well i do not have much to say, with all my life i will for ever be grateful to him and God Almighty for using Dr Agbomian to reach me when i thought it is all over, today i am now happy after the medical doctor have confirmed my status Negative, i have never in my life believed that HEPES could be cure by any herbal medicine. so i want to use this medium to reach other persons who is suffering from any deadly disease you can contact Dr Agbomian on his email: [email protected]

Reply
Carina Campbell
8/26/2024 06:13:19 pm

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moupay martins
10/29/2024 06:42:24 am

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HE ALSO RENDERED THE FOLLOWING ........1. BRING YOUR EX BACK........... 2. LOTTERY SPELL......... 3. PREGNANCY SPELL ..........4. WEAK ERECTION ............5. POOR EJACULATION..........

Reply
Becky Elise
11/6/2024 09:54:52 am

Do not contact any other spell caster to help you so that you will not fall into the wrong hands. Contact Dr Odunga at [email protected] to help you with your fertility, ex back, a love spell, a herbal medicinal cure or lottery winning numbers and you will get awesome results. I met this man through a testimony online and it has been a wonderful experience of a lifetime. I am very happy I did. He helped me get pregnant. I am Becky Elise but my friends call me Ann. I am from Florida, US. I have contacted 3 spell casters before I met Dr Odunga. I would have been through my pain for the past 5 years trying to find the right spell caster who can help me with my problem. I have been married to my husband for 18 years and I have not had one single issue. No woman on earth will be happy about this. I did all I could to hold a home until I started seeking help from spell casters. I had gone to various hospitals here in Florida and they said my womb cannot conceive a child. I have spent thousands of dollars finding a solution until I met DR ODUNGA. I feel like shedding tears at this point. My problem is gone. I can boldly say my problem is gone for the past 18 years of marriage. I am now a mother of twins. If you are reading this testimony, you will share with me my Joy. Contact this spell caster at [email protected] or also Email: [email protected]

Reply
Laura Schneider
11/21/2024 04:12:46 pm

Everyone really needs to start
seeing the value and usefulness of
natural herbs medications. I'm thrilled
with an overwhelming sensation, i finally
got rid of my Herpes with the natural
medicine ordered from Dr Agbonhale it's
indeed an amazing work you're doing
Dr Agbonhale, I'm glad l trusted your herbs i
love you ❤️❤️
Also Have permanent herbal cure for
1) High-Blood pressure
2) Diabetes
3) PCOS
4) HPV e.t.c Contact him, He is 100%
reliable. Via Email: [email protected]
WhatsApp +2349073130326
website/ https://dr-agbonhale-herbal-home.jimdosite.com/

Reply
Laura Schneider
11/21/2024 04:13:12 pm

Everyone really needs to start
seeing the value and usefulness of
natural herbs medications. I'm thrilled
with an overwhelming sensation, i finally
got rid of my Herpes with the natural
medicine ordered from Dr Agbonhale it's
indeed an amazing work you're doing
Dr Agbonhale, I'm glad l trusted your herbs i
love you ❤️❤️
Also Have permanent herbal cure for
1) High-Blood pressure
2) Diabetes
3) PCOS
4) HPV e.t.c Contact him, He is 100%
reliable. Via Email: [email protected]
WhatsApp +2349073130326
website/ https://dr-agbonhale-herbal-home.jimdosite.com/

Reply
Laura Schneider
11/21/2024 04:13:53 pm

Everyone really needs to start
seeing the value and usefulness of
natural herbs medications. I'm thrilled
with an overwhelming sensation, i finally
got rid of my Herpes with the natural
medicine ordered from Dr Agbonhale it's
indeed an amazing work you're doing
Dr Agbonhale, I'm glad l trusted your herbs i
love you ❤️❤️
Also Have permanent herbal cure for
1) High-Blood pressure
2) Diabetes
3) PCOS
4) HPV e.t.c Contact him, He is 100%
reliable. Via Email: [email protected]
WhatsApp +2349073130326
website/ https://dr-agbonhale-herbal-home.jimdosite.com/

Reply
Laura Schneider
11/21/2024 04:14:47 pm

Everyone really needs to start
seeing the value and usefulness of
natural herbs medications. I'm thrilled
with an overwhelming sensation, i finally
got rid of my Herpes with the natural
medicine ordered from Dr Agbonhale it's
indeed an amazing work you're doing
Dr Agbonhale, I'm glad l trusted your herbs i
love you ❤️❤️
Also Have permanent herbal cure for
1) High-Blood pressure
2) Diabetes
3) PCOS
4) HPV e.t.c Contact him, He is 100%
reliable. Via Email: [email protected]
WhatsApp +2349073130326
website/ https://dr-agbonhale-herbal-home.jimdosite.com/

Reply
Laura Schneider
11/21/2024 04:15:41 pm

Everyone really needs to start
seeing the value and usefulness of
natural herbs medications. I'm thrilled
with an overwhelming sensation, i finally
got rid of my Herpes with the natural
medicine ordered from Dr Agbonhale it's
indeed an amazing work you're doing
Dr Agbonhale, I'm glad l trusted your herbs i
love you ❤️❤️
Also Have permanent herbal cure for
1) High-Blood pressure
2) Diabetes
3) PCOS
4) HPV e.t.c Contact him, He is 100%
reliable. Via Email: [email protected]
WhatsApp +2349073130326
website/ https://dr-agbonhale-herbal-home.jimdosite.com/

Reply
Elizabeth Crawford
11/24/2024 08:00:52 am

Dr Agbonhale treatment is 100% guarantee for HSV Cure, the reason why most people are finding it difficult to cure HSV is because they believe on medical report, drugs and medical treatment which is not helpful to cure HSV, Natural root/ herbs are the best remedy which can easily eradicate herpes forever.
write for any health challenges.
Website 👉👉 https://dr-agbonhale-herbal-home.jimdosite.com/
WhatsApp +2349073130326.
Email [email protected]

Reply
KIARA HAHN
12/13/2024 10:08:07 pm


How I Got My Ex Back with the Help of a Spell Caster +2349161779461

Hello everyone, my name is Kiara Hahn from California. I want to share my story about a powerful spell caster named Dr. Jakuta. I was heartbroken when my fiancé left me without warning, and I spent the last month feeling confused, guilty, and devastated. Desperate for help, I searched online for relationship advice and found Dr. Jakuta, who has helped many people with their relationship problems. I reached out to him, and he promised to bring my fiancé back to me within 72 hours. After following his instructions, my fiancé surprisingly showed up at my doorstep, apologized, and now we're living happily together again. If you're having relationship issues, you can contact Dr. Jakuta at:

Email: [email protected]
WhatsApp: +2349161779461

Reply
Jacqueline
12/31/2024 11:08:52 am

My name is Jacqueline Hedges. I never believed I would be cured by a spell caster who specializes in herbal cure and magical spells. I am talking about the help Doctor Odunga gave to me. I have been cured of herpes HPV which has plagued me for over 2 years. I am very happy to tell others that if you want to be cured or get your ex back spells and get pregnant naturally, even financial blessing through lottery, there is only one place to be and that is with Dr Odunga Spell Temple. You should contact him now to help you within 24 hours with your problem at his Email: [email protected] and via Whats App his mobile number +2348167159012.

Reply
Noel Patricio
1/11/2025 12:58:58 pm

A Life-Changing Experience, Dr Kachi A Testimony of Gratitude

I would like to share an extraordinary experience that has transformed my life. I came across a remarkable testimony online forum about a powerful and renowned spell caster, Dr. Kachi. At the time, I was skeptical because I had never encountered anything related to magic or spell casting before. However, the story of Dr. Kachi's work resonated with me, and I decided to give it a chance. For years, my family and I struggled financially, and despite my best efforts, I never had luck winning the lottery. I loved playing, but winning seemed impossible. Everything changed when I connected with Dr. Kachi, who provided me with a winning lottery number through a powerful spell. In just 24 hours, I was able to play the lottery and won the Lotto 6/49 prize, a remarkable $68 million cash prize, on September 27th in the Gold Ball Draw. This incredible win has completely changed my life and the financial well-being of my entire family. After 10 years of trying unsuccessfully, I am now living my dream life. I am beyond grateful to Dr. Kachi for his assistance, Dr. Kachi has truly been a blessing to me and my loved ones. I encourage anyone who is interested to reach out to Dr. Kachi for guidance. his website https://drkachispellcaster.wixsite.com/my-site or email [email protected]. Also reach him text or call +1 (209) 893-8075.Thank you once again, Dr. Kachi, for making my dreams come true.

Reply
victor turley
1/14/2025 08:11:43 am

Holy s**t. Sorry for the language but I cant believe i stumbled across a comment while scouring the internet. I am suffering from erectile dysfunction, which was the same situation i found on the post ,Then I Connected with the email , i saw on the internet . i ordered mine and same with me today am cured , i am now a full man , enjoying my sex life and also got manhood enlarger , now my wife do scream on me and enjoy every part of me , if you also need his assistance , You meant go through his website; https://bubaherbalmiraclem.wixsite.com/website . Or reach him via mail ; [email protected] or whatsapp ; +2349060529305 or his Facebook Page ;https://www.facebook.com/profile.php?id=61559577240930 . AND THANK ME LATER . REACH ME FOR ADVICE +12044101902

Reply
Sweet mssimonej
1/16/2025 10:34:18 am

I Recommend Dr Agbonhale to everyone for his great work for curing me from Herpes with his Herbs Remedy and today i'm cured i am happy to share the good news and to also let everyone know how great his herbs remedy is with no side effect i am free from the herpes virus with no side effects, kindly reach him out WhatsApp +2349073130326  Email: [email protected]   website:  https://dr-agbonhale-herbal-home.jimdosite.com/  

Reply
Lilian Jose
1/31/2025 07:32:31 am

I want to use this opportunity to testify of the marvelous work of Dr. Odunga and how he has helped me in curing my sickness and bringing happiness into my life. I can really vouch for Dr. Odunga in herbal treatment. I was suffering from Cervical Cancer and infected with HPV 16. I used to have incessant bleeding and there was nothing I could do until a childhood friend introduced me to Dr. Odunga Remedies. I spoke with him and ordered his recommended medication which was delivered to me through DHL. Immediately I began using the herbal medicine, within a  week I couldn't feel any pain. It took me 2 weeks to finish the medicine and afterwards I was completely cured. I highly recommend that you contact him to help you at his email [email protected] OR What'sApp/Call him at +2348167159012

He is 100% reliable to help you too.

Reply
James Turley
2/5/2025 02:41:48 am

I was really stressed by Erectile dysfunction issues and had consulted Dr Moses Buba. He gave us a thorough consultation and the medicines were equally effective. In a couple of weeks there was big improvement in me and we are very pleased with the progress. We cannot thank Dr Moses Buba enough. Highly recommended.you can reach him via Email [email protected] WhatsApp +2349060529305. you can also reach on his Facebook page ; https://www.facebook.com/profile.php?id=61559577240930 / website page https://bubaherbalmiraclem.wixsite.com/website

Reply
micheal pevet link
3/7/2025 02:58:44 pm

NATURAL WAY TO GET HERPES1&2 CURED. If you have been looking for ways to naturally get rid of the herpes simplex virus from your body completely, then you are welcome to read further. Let's face reality here, you have tried so many counter drugs and you are confused, weak and angry because nothing seems to work. Good News For you my friend.... Yes, I came with good news that will liberate you from the pains and stress of herpes outbreak, you will get total cure from this virus using Dr. MOSES BUBA Herbal Methodology. Who is Dr. MOSES BUBA? You may ask. Dr. MOSES BUBA is a herbalist and a naturalist. He researched and identified some herbs and established a unique methodology to healing the human body using Herbal medicine that was confidently entrenched in his over 30 years of experience. According to him, he has the cure for so many diseases/virus like GENITAL HERPES, HIV, DIABETES, CANCER, HPV, HSV1&2, GENITAL WART, SHINGLES, VAGINAL INFECTION and so many more. You can reach Dr MOSES BBUBA on his email: [email protected] / WhatsApp +2349060529305 . You can also contact him through his website: https://bubaherbalmiraclem.wixsite.com/website. Facebook page : https://www.facebook.com/profile.php?id=61559577240930 . I am using this medium to inform everyone how to get treated of herpes using Dr MOSES BUBA recommended Herbal methodology.

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GUFF jack
4/19/2025 05:29:42 am

Holy s**t. Sorry for the language but I cant believe i stumbled across a comment while scouring the internet. I am suffering from erectile dysfunction, which was the same situation i found on the post ,Then I Connected with the email , i saw on the internet . i ordered mine and same with me today am cured , i am now a full man , enjoying my sex life and also got manhood enlarger , now my wife do scream on me and enjoy every part of me , if you also need his assistance , You meant go through his website; https://bubaherbalmiraclem.wixsite.com/website . Or reach him via mail ; [email protected] or WhatsApp ; +2349060529305 or his Facebook Page ;https://www.facebook.com/profile.php?id=61559577240930 . AND THANK ME LATER . REACH ME FOR ADVICE +12044101902

Reply
Tamino
5/9/2025 11:37:44 am

Cancer, can be treated and cured permanently but only few believe it,, but I was among those who never believed it until doctor herbal cured me of Cancer, I had Cancer for two years and it was eating me one day I found a testimony of someone testifying to the great work of Dr Moses Buba who cured him of Cancer, I was thinking since this man can cure Cancer then . must be able to cure my Cancer too and to my greatest surprise he really cured me of Cancer, I only message him on his email( buba.herbalmiraclemedicine@gmail ) and he replied me and we discussed then he sent me the medicine and today am Cancer free... All thanks to you Dr Moses Buba the herbalist.. Thank you. Contact Dr Moses Buba for any help
https://www.facebook.com/profile.php?id=61559577240930

Reply



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